作者: wahaha99 (此方不可長) 看板: Gossiping
標題: Re: [新聞] 類愛滋怪病現台灣 病因仍不明
時間: Thu Aug 23 20:13:59 2012
看樣子事情有點大條
http://www.nejm.org/doi/full/
Adult-Onset Immunodeficiency in Thailand and [1;31;40mTaiwan [m
在泰國與台灣發生的成人免疫缺陷疾病
BACKGROUND
Autoantibodies against interferon-γ are associated with severe disseminated
opportunistic infection, [1;36;40mbut their importance and prevalence are unknown. [m
..他們的重要性與感染率仍未知。
METHODS
We enrolled 203 persons from sites in Thailand and Taiwan in five groups: 52
patients with disseminated, rapidly or slowly growing, nontuberculous
mycobacterial infection (group 1); 45 patients with another opportunistic
infection, with or without nontuberculous mycobacterial infection (group 2);
9 patients with disseminated tuberculosis (group 3); 49 patients with
pulmonary tuberculosis (group 4); and 48 healthy controls (group 5). Clinical
histories were recorded, and blood specimens were obtained.
RESULTS
Patients in groups 1 and 2 had CD4+ T-lymphocyte counts that were similar to
those in patients in groups 4 and 5, and [1;36;40mthey were not infected with the
[1;36;40mhuman immunodeficiency virus (HIV) [m. Washed cells obtained from patients in
groups 1 and 2 had intact cytokine production and a response to cytokine
stimulation. In contrast, plasma obtained from these patients inhibited the
activity of interferon-γ in normal cells. High-titer anti–interferon-γ
autoantibodies were detected in 81% of patients in group 1, 96% of patients
in group 2, 11% of patients in group 3, 2% of patients in group 4, and 2% of
controls (group 5). Forty other anticytokine autoantibodies were assayed. One
patient with cryptococcal meningitis had autoantibodies only against
granulocyte–macrophage colony-stimulating factor. [1;36;40mNo other anticytokine
[1;36;40mautoantibodies or genetic defects correlated with infections. There was no
[1;36;40mfamilial clustering. [m
太專業所以沒法全看懂
大致上藍字是說患病者
．他們沒有感染HIV
．沒有基因缺陷
．沒有家族聚集性
CONCLUSIONS
Neutralizing anti–interferon-γ autoantibodies were detected in 88% of Asian
adults with multiple opportunistic infections and were associated with an
adult-onset immunodeficiency akin to that of advanced HIV infection. (Funded
by the National Institute of Allergy and Infectious Diseases and the National
Institute of Dental and Craniofacial Research; ClinicalTrials.gov number,
NCT00814827.)
有請讀醫學或生化的翻譯一下吧
要等那腦殘痴呆的馬政府動起來可能台灣都早已滅絕了
※ 引述《SlimeKnight (protect)》之銘言：
: 類愛滋怪病現台灣 病因仍不明
: http://newtalk.tw/news_read.
: 新頭殼newtalk 2012.08.23 柯昱安/綜合報導
: 根據美聯社報導，近年來台灣、泰國等亞洲國家，
: ，患者在沒有感染愛滋病毒（HIV）的情況下，
: 死亡，儘管研究人員指出此病不具傳染性，但患病原因至今仍未明。
: 美國國立過敏與傳染病研究院（National Institute of Allergy and Infectious
: Diseases）科學家布朗（Sarah Brown），領導台灣與泰國研究人員從事這項疾病的
: 研究。研究報告今（23）日發表，據了解，
: 出現在泰國與台灣。
: 這種疾病被研究人員稱做「成人型」免疫缺陷症，
: 身上。據了解，該病非與愛滋病一般由病毒傳播，也不是遺傳疾病，
: 途徑至今仍未明。
: 布朗表示，該疾病是繼愛滋病之後，另一種後天免疫缺乏症，
: 壞，無法如一般健康的人體抵抗細菌。
: 1種抑制抗體的癌症用藥，藉此抑制感染。不過研究人員仍擔心，
: 系統不全的病患，仍有可能受到慢性疾病之苦。
--
※ 發信站: 批踢踢實業坊(ptt.cc)
◆ From: 1.34.41.207
[1;37m推 [33mclkdtm32 [m [33m:這無解吧 什麼都不是 但是就是有病 太扯... [m 08/23 20:16
[1;37m推 [33mPPPGGG [m [33m:這之前不是有報導 美國也有? [m 08/23 20:16
[1;37m推 [33mynd [m [33m:性別混亂性病毒? kaka [m 08/23 20:17
[1;37m推 [33mmecca [m [33m:沒空 現在只關心放不放假 [m 08/23 20:17
[1;37m推 [33mc4681209 [m [33m:甲甲會變多？ [m 08/23 20:18
[1;37m推 [33mCP543 [m [33m:搞不好是禽流感病毒突變 [m 08/23 20:21
[1;31m→ [33mserratia [m [33m:關鍵字自體抗體沒翻出來... [m 08/23 20:22
不會翻啊 內容太專業了...
[1;31m→ [33mgca00631 [m [33m:性病的話我就不用擔心了 [m 08/23 20:22
想的好咧 什麼途徑都不知道 捐血也不會篩檢的
※ 編輯: wahaha99 來自: 1.34.41.207 (08/23 20:25)
[1;37m推 [33mKTR5566 [m [33m:那有沒有甲甲? [m 08/23 20:24
還乙乙咧...
※ 編輯: wahaha99 來自: 1.34.41.207 (08/23 20:26)
[1;31m→ [33mkasamewon [m [33m:要看關鍵字決定參戰ID [m 08/23 20:25
[1;37m推 [33mseason002 [m [33m:上次那個指甲替代毛髮的長出來的也很奇怪 怪病真多 [m 08/23 20:26
[1;37m推 [33mturbomons [m [33m:患者會生成一種類似自身抗體的物質，
[1;31m→ [33mturbomons [m [33m:化學訊號干擾素γ [m 08/23 20:28
[1;31m→ [33mturbomons [m [33m:感覺像自體免疫疾病 應該不會傳染 [m 08/23 20:29
如果是存在已久的疾病, 應該不會現在才發現吧
那只能從傳染病跟污染兩個角度考慮了?
但污染的話群聚效應會很明顯呀...
該不會又是像PrPsc那種怪蛋白吧
※ 編輯: wahaha99 來自: 1.34.41.207 (08/23 20:32)
[1;31m→ [33mserratia [m [33m:目前還不清楚引發這種自體抗體的原因 [m 08/23 20:34
[1;31m→ [33mturbomons [m [33m:如果像Prion那種就恐怖了~~ [m 08/23 20:35
[1;31m→ [33mmomogo11 [m [33m:真毛 [m 08/23 20:37
[1;37m推 [33mlaukun [m [33m:現在不防疫 又會重演廢騜當初 SARS大流行的台北鬼城 [m 08/23 20:45
[1;31m噓 [33moldchang1205 [m [33m:非病毒傳播 又不知道怎致病 防疫個雕? [m 08/23 21:02
[1;37m推 [33mmagma [m [33m:這跟愛滋是不同機轉 應該是新發現的自體免疫疾病 [m 08/23 21:04
[1;31m→ [33mmagma [m [33m:因為患者的CD4 T細胞的數目跟正常人相近 而愛滋是T細胞減少 [m 08/23 21:05
[1;31m→ [33mmagma [m [33m:看起來像是不明原因讓病人體內產生對抗IFN-
[1;31m→ [33mmagma [m [33m:因為IFN-r本身是一種可以刺激細胞免疫的激素 所以會造成 [m 08/23 21:08
[1;31m→ [33mmagma [m [33m:病人的IFN-r沒有辦法發揮作用 (因為被抗體中和了) 進而讓病 [m 08/23 21:10
[1;31m→ [33mmagma [m [33m:人面對外來伺機性感染時的免疫力下降 [m 08/23 21:10
[1;31m→ [33mmagma [m [33m:
[1;31m→ [33mmagma [m [33m:因為打字方便把 interferon-γ簡單以IFN-r表示 請見諒 [m 08/23 21:15
[1;37m推 [33mHornyDragon [m [33m:媽的一堆腦殘，整個就完全不一樣的神秘疾病， [m 08/23 21:16
[1;31m→ [33mHornyDragon [m [33m:還在那邊甲甲甲甲，腦子只有甲甲是不是。 [m 08/23 21:16
[1;37m推 [33mEggAcme [m [33m:某人腦袋只有甲而已阿 我懷疑他是不是被肛過心靈受創 [m 08/24 03:48
標題: Re: [新聞] 類愛滋怪病現台灣 病因仍不明
時間: Thu Aug 23 20:13:59 2012
看樣子事情有點大條
http://www.nejm.org/doi/full/
Adult-Onset Immunodeficiency in Thailand and [1;31;40mTaiwan [m
在泰國與台灣發生的成人免疫缺陷疾病
BACKGROUND
Autoantibodies against interferon-γ are associated with severe disseminated
opportunistic infection, [1;36;40mbut their importance and prevalence are unknown. [m
..他們的重要性與感染率仍未知。
METHODS
We enrolled 203 persons from sites in Thailand and Taiwan in five groups: 52
patients with disseminated, rapidly or slowly growing, nontuberculous
mycobacterial infection (group 1); 45 patients with another opportunistic
infection, with or without nontuberculous mycobacterial infection (group 2);
9 patients with disseminated tuberculosis (group 3); 49 patients with
pulmonary tuberculosis (group 4); and 48 healthy controls (group 5). Clinical
histories were recorded, and blood specimens were obtained.
RESULTS
Patients in groups 1 and 2 had CD4+ T-lymphocyte counts that were similar to
those in patients in groups 4 and 5, and [1;36;40mthey were not infected with the
[1;36;40mhuman immunodeficiency virus (HIV) [m. Washed cells obtained from patients in
groups 1 and 2 had intact cytokine production and a response to cytokine
stimulation. In contrast, plasma obtained from these patients inhibited the
activity of interferon-γ in normal cells. High-titer anti–interferon-γ
autoantibodies were detected in 81% of patients in group 1, 96% of patients
in group 2, 11% of patients in group 3, 2% of patients in group 4, and 2% of
controls (group 5). Forty other anticytokine autoantibodies were assayed. One
patient with cryptococcal meningitis had autoantibodies only against
granulocyte–macrophage colony-stimulating factor. [1;36;40mNo other anticytokine
[1;36;40mautoantibodies or genetic defects correlated with infections. There was no
[1;36;40mfamilial clustering. [m
太專業所以沒法全看懂
大致上藍字是說患病者
．他們沒有感染HIV
．沒有基因缺陷
．沒有家族聚集性
CONCLUSIONS
Neutralizing anti–interferon-γ autoantibodies were detected in 88% of Asian
adults with multiple opportunistic infections and were associated with an
adult-onset immunodeficiency akin to that of advanced HIV infection. (Funded
by the National Institute of Allergy and Infectious Diseases and the National
Institute of Dental and Craniofacial Research; ClinicalTrials.gov number,
NCT00814827.)
有請讀醫學或生化的翻譯一下吧
要等那腦殘痴呆的馬政府動起來可能台灣都早已滅絕了
※ 引述《SlimeKnight (protect)》之銘言：
: 類愛滋怪病現台灣 病因仍不明
: http://newtalk.tw/news_read.
: 新頭殼newtalk 2012.08.23 柯昱安/綜合報導
: 根據美聯社報導，近年來台灣、泰國等亞洲國家，
: ，患者在沒有感染愛滋病毒（HIV）的情況下，
: 死亡，儘管研究人員指出此病不具傳染性，但患病原因至今仍未明。
: 美國國立過敏與傳染病研究院（National Institute of Allergy and Infectious
: Diseases）科學家布朗（Sarah Brown），領導台灣與泰國研究人員從事這項疾病的
: 研究。研究報告今（23）日發表，據了解，
: 出現在泰國與台灣。
: 這種疾病被研究人員稱做「成人型」免疫缺陷症，
: 身上。據了解，該病非與愛滋病一般由病毒傳播，也不是遺傳疾病，
: 途徑至今仍未明。
: 布朗表示，該疾病是繼愛滋病之後，另一種後天免疫缺乏症，
: 壞，無法如一般健康的人體抵抗細菌。
: 1種抑制抗體的癌症用藥，藉此抑制感染。不過研究人員仍擔心，
: 系統不全的病患，仍有可能受到慢性疾病之苦。
--
※ 發信站: 批踢踢實業坊(ptt.cc)
◆ From: 1.34.41.207
[1;37m推 [33mclkdtm32 [m [33m:這無解吧 什麼都不是 但是就是有病 太扯... [m 08/23 20:16
[1;37m推 [33mPPPGGG [m [33m:這之前不是有報導 美國也有? [m 08/23 20:16
[1;37m推 [33mynd [m [33m:性別混亂性病毒? kaka [m 08/23 20:17
[1;37m推 [33mmecca [m [33m:沒空 現在只關心放不放假 [m 08/23 20:17
[1;37m推 [33mc4681209 [m [33m:甲甲會變多？ [m 08/23 20:18
[1;37m推 [33mCP543 [m [33m:搞不好是禽流感病毒突變 [m 08/23 20:21
[1;31m→ [33mserratia [m [33m:關鍵字自體抗體沒翻出來... [m 08/23 20:22
不會翻啊 內容太專業了...
[1;31m→ [33mgca00631 [m [33m:性病的話我就不用擔心了 [m 08/23 20:22
想的好咧 什麼途徑都不知道 捐血也不會篩檢的
※ 編輯: wahaha99 來自: 1.34.41.207 (08/23 20:25)
[1;37m推 [33mKTR5566 [m [33m:那有沒有甲甲? [m 08/23 20:24
還乙乙咧...
※ 編輯: wahaha99 來自: 1.34.41.207 (08/23 20:26)
[1;31m→ [33mkasamewon [m [33m:要看關鍵字決定參戰ID [m 08/23 20:25
[1;37m推 [33mseason002 [m [33m:上次那個指甲替代毛髮的長出來的也很奇怪 怪病真多 [m 08/23 20:26
[1;37m推 [33mturbomons [m [33m:患者會生成一種類似自身抗體的物質，
[1;31m→ [33mturbomons [m [33m:化學訊號干擾素γ [m 08/23 20:28
[1;31m→ [33mturbomons [m [33m:感覺像自體免疫疾病 應該不會傳染 [m 08/23 20:29
如果是存在已久的疾病, 應該不會現在才發現吧
那只能從傳染病跟污染兩個角度考慮了?
但污染的話群聚效應會很明顯呀...
該不會又是像PrPsc那種怪蛋白吧
※ 編輯: wahaha99 來自: 1.34.41.207 (08/23 20:32)
[1;31m→ [33mserratia [m [33m:目前還不清楚引發這種自體抗體的原因 [m 08/23 20:34
[1;31m→ [33mturbomons [m [33m:如果像Prion那種就恐怖了~~ [m 08/23 20:35
[1;31m→ [33mmomogo11 [m [33m:真毛 [m 08/23 20:37
[1;37m推 [33mlaukun [m [33m:現在不防疫 又會重演廢騜當初 SARS大流行的台北鬼城 [m 08/23 20:45
[1;31m噓 [33moldchang1205 [m [33m:非病毒傳播 又不知道怎致病 防疫個雕? [m 08/23 21:02
[1;37m推 [33mmagma [m [33m:這跟愛滋是不同機轉 應該是新發現的自體免疫疾病 [m 08/23 21:04
[1;31m→ [33mmagma [m [33m:因為患者的CD4 T細胞的數目跟正常人相近 而愛滋是T細胞減少 [m 08/23 21:05
[1;31m→ [33mmagma [m [33m:看起來像是不明原因讓病人體內產生對抗IFN-
[1;31m→ [33mmagma [m [33m:因為IFN-r本身是一種可以刺激細胞免疫的激素 所以會造成 [m 08/23 21:08
[1;31m→ [33mmagma [m [33m:病人的IFN-r沒有辦法發揮作用 (因為被抗體中和了) 進而讓病 [m 08/23 21:10
[1;31m→ [33mmagma [m [33m:人面對外來伺機性感染時的免疫力下降 [m 08/23 21:10
[1;31m→ [33mmagma [m [33m:
[1;31m→ [33mmagma [m [33m:因為打字方便把 interferon-γ簡單以IFN-r表示 請見諒 [m 08/23 21:15
[1;37m推 [33mHornyDragon [m [33m:媽的一堆腦殘，整個就完全不一樣的神秘疾病， [m 08/23 21:16
[1;31m→ [33mHornyDragon [m [33m:還在那邊甲甲甲甲，腦子只有甲甲是不是。 [m 08/23 21:16
[1;37m推 [33mEggAcme [m [33m:某人腦袋只有甲而已阿 我懷疑他是不是被肛過心靈受創 [m 08/24 03:48
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